Histiocytic lymphoma cell lines: Immunologic and cytogenetic studies
Identifieur interne : 000C61 ( Main/Exploration ); précédent : 000C60; suivant : 000C62Histiocytic lymphoma cell lines: Immunologic and cytogenetic studies
Auteurs : Barbara Kaiser-Mccaw Hecht [États-Unis] ; Alan L. Epstein [États-Unis] ; Carol S. Berger [États-Unis] ; Henry S. Kaplan [États-Unis] ; Frederick Hecht [États-Unis]Source :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1984.
English descriptors
- Teeft :
- Abnormality, Biomedical research institute, Cell line, Cell lines, Cell lymphomas, Cell type, Chain genes, Chromosomal, Chromosome, Cytogenetic, Cytogenetic studies, Diffuse, Diffuse histiocytic, Epstein, Hecht, Histiocytic, Histiocytic lymphoma cell lines, Human chromosomes, Human immunoglobulin, Immunoglobulin, Intermediate grade, Kaplan, Karyotype, Large cell, Large cell immunoblastic, Leukemia, Lymphocytic, Lymphoma, Lymphoma cell lines, Malignant, Malignant lymphoma, Malignant lymphomas, Marker chromosome, Null cell, Oncogene, Proc natl acad, Rearrangement, Translocation.
Abstract
Abstract: Cell lines were established from 15 patients with diffuse histiocytic lymphoma (DHL) of the intermediate grade, diffuse large cell (class G), and high-grade, large cell immunoblastic (class H) types. Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.
Url:
DOI: 10.1016/0165-4608(85)90186-4
Affiliations:
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Immunologic studies indicated that 11 of the 15 DHL cell lines were B cell in origin, 2 were histiocytic, and 2 were null cell. Cytogenetic studies revealed 1 hypodiploid, 11 hyperdiploid, and 3 near-tetraploid cell lines. Chromosome #7 was trisomic in 3 lines, chromosomes #12 in 4 lines, and chromosome #13 in 3 lines. Chromosome #2 was monosomic in 3 lines, chromosome #8 was monosomic in 5 lines, chromosome #14 in 4 lines, and chromosome #22 in 6 cell lines. This is of special interest, as chromosomes #2, #8, #14, and #22 are clearly concerned with rearrangements in Burkitt's lymphoma and immunoglobulin expression. The most common rearrangement in the DHL cell lines involved chromosome #14 at band 14q32. However, in contrast to Burkitt's lymphoma, the pattern of translocation in DHL is between chromosome #14 and usually chromosome #11 or chromosome #18. The 14;18 translocation is not restricted to patients with low-grade follicular, small cleaved cell lymphomas, as has been reported. The 14q+ chromosome is characteristic of lymphoid malignancies in general. It is due, invariably, to a translocation with the breakpoint in band 14q32, which is the locus of the immunoglobulin heavy chain genes. We propose that in each translocation, for example, chromosomes #11 or #18, an oncogene may be transposed onto chromosome #14, and that each 14q+ translocation in DHL represents an event that transposes an oncogene from another chromosome to chromosome #14.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li><li>Californie</li><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Hecht, Barbara Kaiser Mccaw" sort="Hecht, Barbara Kaiser Mccaw" uniqKey="Hecht B" first="Barbara Kaiser-Mccaw" last="Hecht">Barbara Kaiser-Mccaw Hecht</name></region><name sortKey="Berger, Carol S" sort="Berger, Carol S" uniqKey="Berger C" first="Carol S." last="Berger">Carol S. Berger</name><name sortKey="Epstein, Alan L" sort="Epstein, Alan L" uniqKey="Epstein A" first="Alan L." last="Epstein">Alan L. Epstein</name><name sortKey="Hecht, Frederick" sort="Hecht, Frederick" uniqKey="Hecht F" first="Frederick" last="Hecht">Frederick Hecht</name><name sortKey="Kaplan, Henry S" sort="Kaplan, Henry S" uniqKey="Kaplan H" first="Henry S." last="Kaplan">Henry S. Kaplan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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